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Quiz: Take Healthy Living for Every Age HERE

An aging body has changed in many ways, and not just in those obvious to visual inspection. The typical old body is identifiably different from the typical middle-aged body at the level of cells, genes and biochemistry: biochemical processes, gene expression, levels of molecular damage, cellular behaviors, cellular populations, and so on.

Some of these differences are clearly causally linked - a wide range of age-related changes can often be shown to be caused by a lesser number of underlying changes. For example, damage to mitochondria leads to oxidization of low-density lipoproteins (LDL), which in turn leads to detrimental changes involved in atherosclerosis, which is the principal cause of coronary heart disease and other forms of cardiovascular disease. Most modes of biochemical wear and tear contribute to a wide range of recognized age-related conditions and frailty.

One role of aging research should be to explore these linkages, so as to better characterize the core of aging; what, really, are the essential changes of aging when all the chains of failure have been cut back to their root causes? Read on

BREAKTHROUGH:STOP MEMORY LOSS

MS lesions within the brain and spinal cord are produced when inflammatory processes mistakenly attack myelin, the insulating sheath around nerve fibres. It has long been thought that the reconstitution and repair of damaged myelin might help reverse disease. One way to achieve this would be to provide the body with new myelin-producing cells, known as oligodendrocytes, to rebuild the myelin which has been lost. This is the goal of stem cell research, which uses reprogrammed cells that are capable of developing into many different cell types to treat disease. Often, the focus of MS research has been on how to generate and treat myelin loss with oligodendrocyte progenitor cells (OPCs), the precursor cells that develop into oligodendrocytes.

This has previously been achieved with stem cells made from foetal tissue, but researchers from the University of Rochester Medical Centre are the first to successfully create OPCs from skin cells.Read on

ALCHEMY OF SUCCESS

GOOD ALCHEMY IS GREAT